In today's fields of biological science and medicine, nucleic acid detection is undoubtedly a shining star, widely used in many key areas such as disease diagnosis, genetic research, forensic identification, and more. Behind all these applications, nucleic acid extraction, as the primary and crucial step, lays a solid foundation for subsequent precise analysis.

ArchiPure Series Automated Nucleic Acid Extractor

DNA Extraction

The Key to Unlocking the Code of Life

DNA, the miraculous molecule containing the genetic information of living organisms, is like a heavenly book of life. The main purpose of DNA extraction is to obtain pure and intact genomic DNA, enabling numerous scientific researches and practical applications.

Medical Diagnosis

By extracting DNA from patient samples, hereditary diseases can be accurately detected. For example, for certain monogenic diseases such as cystic fibrosis and thalassemia, DNA extraction followed by gene sequencing can identify the mutation types of pathogenic genes, providing an indispensable basis for early diagnosis, genetic counseling, and the formulation of personalized treatment plans.

Criminal Investigation

DNA extraction is also a critical tool for solving crimes. Trace biological samples such as hair, blood, and saliva left at crime scenes, after careful DNA extraction and comparison with the suspect database, can often point the direction for case detection and reveal the truth.

Genetic Engineering and Biotechnology Research

Extracting DNA from specific organisms is the primary step in gene cloning, gene editing, and the development of transgenic technologies. By manipulating DNA, scientists can create new biological varieties with specific excellent traits, bringing unlimited possibilities for agricultural production and biomedical innovation.

The ArchiPure Series Automated Nucleic Acid Extraction and Purification System demonstrates outstanding performance in DNA extraction. It adopts advanced magnetic bead technology. The biological magnetic beads, as the core of the technology, can specifically and efficiently bind DNA, greatly improving extraction efficiency. Its automated workflow, combined with ArchiPure series matching kits, requires minimal manual intervention from sample lysis, DNA adsorption to elution. Compared with traditional precipitation and column purification methods, most samples can complete specific binding of magnetic beads and nucleic acids within 15–40 minutes, while significantly improving the purity and yield of extraction. Compared with traditional manual extraction, ArchiPure reduces human error and ensures stable and reliable results through precise instrument control, providing high-quality samples for subsequent DNA analysis.

RNA Extraction

Listening to the Voice of Cells

As a key messenger in the transmission of genetic information from DNA to proteins, RNA plays a central role in cellular functional regulation and gene expression. The purpose of RNA extraction is mainly to study gene transcription and expression, thereby further exploring the laws of cellular life activities.

Basic Medical Research

By extracting and analyzing RNA from different tissues and cells under physiological and pathological conditions, changes in gene expression during disease development can be revealed. For example, in cancer research, comparing RNA expression profiles between tumor and normal tissues can identify key genes related to tumorigenesis and metastasis, providing important clues for the development of early diagnostic markers and targeted therapeutic drugs for tumors.

Drug Research and Development

RNA extraction and analysis help evaluate the effects of drugs on cellular gene expression. By observing changes in cellular RNA levels before and after drug treatment, the mechanism of action, efficacy, and potential side effects of drugs can be understood, accelerating the development process and improving the success rate of new drugs.

Molecular Biology Experiments

Extracting high-quality RNA is a prerequisite for techniques such as reverse transcription PCR (RT-PCR), quantitative real-time PCR (qRT-PCR), and RNA sequencing. These techniques can accurately quantify the expression levels of specific genes, providing strong data support for gene function research.

The ArchiPure Automated Nucleic Acid Extraction and Purification System also features excellent performance for RNA extraction. Its optimized lysis buffer formulation rapidly and gently lyses cells, effectively protecting RNA integrity and avoiding degradation caused by excessive lysis or chemical damage. Meanwhile, the instrument’s precise temperature control system maintains suitable temperatures during key steps such as lysis and elution, ensuring high-quality RNA extraction. Its fast magnetic bead separation module completes RNA extraction and purification in the shortest time, minimizing the risk of RNA degradation. Highly efficient genomic DNA removal technology, combining special enzyme treatment and magnetic bead adsorption, ensures extremely high purity of extracted RNA samples, meeting the stringent requirements of various downstream applications.

ROCGENE Nucleic Acid Extraction Solutions

Both DNA and RNA extraction play irreplaceable roles in their respective fields. The ArchiPure Automated Nucleic Acid Extraction and Purification System and its supporting reagents, with outstanding performance, efficient automated processes, and stable and reliable results, have become reliable assistants in nucleic acid extraction.

Supporting Reagents

Test Results of Universal Magnetic Bead Method for Rapid Viral DNA/RNA Extraction Reagent

To address the many challenges in sample nucleic acid processing, Rocgene has also launched automated nucleic acid extraction and purification solutions with different throughputs — ArchiPure, Archipure Kit, and Archimed. Rapid and efficient nucleic acid extraction and purification combined with one-stop nucleic acid detection shorten the minimum detection time to one hour, freeing you from complicated extraction work.

Recommended Application Scenarios: Testing laboratories with limited experimental space, low sample throughput, and priority on portability and efficiency, such as P2/P3 laboratories, small and medium-sized testing laboratories, secondary or lower hospitals, small hospitals, and pathology departments of health centers.

Recommended Application Scenarios: Compatible with single reagents, available for immediate testing upon sample arrival, cost-effective. Suitable for small laboratories, secondary hospitals, or veterinary testing with small sample volumes and variable sample types.

Recommended Application Scenarios: Medium and large testing laboratories, including CDCs at all levels, animal disease control centers, independent medical laboratories, biotechnology companies, large hospitals, and physical examination centers.